Norman Leigh Anderson




1.         Site of the amino-acid substitution in h¾moglobin Seattle (aAb270Asp). Anderson, N.L., Perutz, M.F., and Stammatoyannopoulos, G. Nature New Biology 243, 274-275, 1973.


2.         Intermediate structure of normal human h¾moglobin: Meth¾moglobin in deoxy quaternary conformation. Anderson, N.L. J. Mol. Biol. 79, 495-506, 1973.


3.         H¾moglobin San Diego (b109(G11)Val->Met): Crystal structure of the deoxy form. Anderson, N.L. J. Clin. Invest. 53, 329-333, 1974.


4.         Structure of deoxy and carbonmonoxy h¾moglobin Kansas in the deoxy quaternary conformation. Anderson, N.L., J. Mol Biol., 94, 33-409, 1975.


5.         Analytical techniques for cell fractions. XIX. The cyclum: An automatic system for cyclic chromatography. Anderson, N.G., Willis, D.D., Holladay, D.W., Caton, J.E., Holleman, J.W., Eveleigh, J.W., Attrill, J.E., Ball, F.L., and Anderson, N.L. Anal. Biochem., 66, 159-174, 1975.


6.         Analytical techniques for cell fractions. XX. Cyclic affinity chromatography: Principles and applications. Anderson, N.G., Willis, D.D., Holladay, D.W., Caton, J.E., Holleman, J.W., Eveleigh, J.W., Attrill, J.E., Ball, F.L., and Anderson, N.L. Anal. Biochem, 68, 371-393, 1975.


7.         H¾moglobin St. Louis (b28(B10)Leu->Glu): Crystal structure of the deoxy form. Anderson, N.L. J. Clin. Invest., 1976.


8.         High resolution two-dimensional electrophoresis of human plasma proteins. Anderson, N.L., and Anderson, N.G. Proc Nat. Acad. Sci. USA 74, 5421-5425, 1977.


9.         Analytical techniques for cell fractions. XXI. Two-dimensional analysis of serum and tissue proteins: Multiple isoelectric focusing. Anderson, N.G. and Anderson, N.L. Anal. Biochem. 85, 331-340, 1978.


10.      Analytical techniques for cell fractions. XXII. Two-dimensional analysis of serum and tissue proteins: Multiple gradient slab gel electrophoresis. Anderson, N.L. and Anderson, N.G. Anal. Biochem. 85, 341-354, 1978.


11.      Analytical techniques for cell fractions. XXIII. A stable thermal gradient device for heat denaturation studies on proteins. Anderson, N.L., Eisler, W.J., and Anderson, N.G. Anal. Biochem. 91, 441-445, 1978.


12.      Molecular anatomy. Anderson, N.G. and Anderson, N.L. Behring Inst. Mitt. 63, 169-210, 1979.


13.      Analytical techniques for cell fractions. XXIV. Isoelectric standards for two-dimensional electrophoresis. Anderson, N.L. and Hickman, B.J. Anal. Biochem. 93, 312-320, 1979.


14.      Analytical techniques for cell fractions. XXV. Concentration and two-dimensional electrophoretic analysis of human urinary proteins. Anderson, N.G., Anderson, N.L., Tollaksen, S.L., Hahn, H., Giere, F., and Edwards, J. Anal. Biochem. 95, 48-61, 1979.


15.      Red cell proteins. I. Two-dimensional mapping of human erythrocyte proteins. Edwards, J.J., Anderson, N.G., Nance, S.L., and Anderson, N.L. Blood, 53, 1121-1132, 1979.


16.      Proteins of human urine. I. Concentration and analysis by two-dimensional electrophoresis. Anderson, N.G., Anderson, N.L., and Tollaksen, S.L. Clin. Chem. 25, 1199-1210, 1979.


17.      Muscle protein analysis. I. Development of high resolution two-dimensional electrophoresis of skeletal muscleproteins for analysis of microbiopsy samples. Giometti, C.S., Anderson, N.G., and Anderson, N.L. Clin. Chem. 25, 1877-1884, 1979.


18.      Analytical techniques for cell fractions. XXVI. Two-dimensional electrophoretic analysis of basic proteinsusing phosphatidyl choline/urea solubilization. Willard, K.E., Giometti, C.S., Anderson, N.L., O'Connor, T.E., and Anderson, N.G. Anal. Biochem. 100, 289-298, 1979.


19.      Microheterogeneity of serum transferrin, haptoglobin, and a2 glycoprotein examined by high-resolution two-dimensional electrophoresis. Anderson, N.L. and Anderson, N.G. Biochem, Biophys. Res. Commun. 88, 258-265, 1979.


20.      The b and g cytoplasmic actins are differentially thermostabilized by MgADP: g actin binds MgADP more strongly. Anderson, N.L., Biochem. Biophys. Res. Commun. 89, 486-490, 1979.


21.      High resolution two-dimensional electrophoretic mapping of human proteins. Anderson, N.L., Edwards, J.J., Giometti, C.S., Willard, K.E., Tollaksen, S.L., Nance, S.L., Hickman, B.J., Taylor, J., Coulter, B., Scandora, A., and Anderson, N.G., Electrophoresis '79, B. Radola, ed., W. DeGruyter, pp 313-328, 1980.


22.      Analytical techniques for cell fractions. XXVII. Use of heart proteins as reference standards in two-dimensional electrophoresis. Giometti, C.S., Anderson, N.G., Tollaksen, S.L., Edwards, J.J., and Anderson, N.L. Anal. Biochem. 102, 47-58, 1980.


23.      Analytical techniques for cell fractions. XXVIII. Dissection of complex antigenic mixtures using monoclonal antibodies and two-dimensional gel electrophoresis. Pearson, T. and Anderson, N.L. Anal. Biochem. 101, 377-386, 1980.


24.      Internal charge standardization for two-dimensional electrophoresis. Hickman, B.J., Anderson, N.L., Willard, K.E., and Anderson, N.G. Electrophoresis '79, B. Radola, ed., W. deGruyter, pp 341-350, 1980.


25.      Alterations of two-dimensional electrophoretic maps of human peripheral blood lymphocytes induced by concanavalin A. Willard, K.E. and Anderson, N.L. Electrophoresis '70, B. Radola, ed. W. deGruyter, pp 415-424, 1980.


26.      Estimation of two-dimensional electrophoretic spot intensities and positions by modeling. Taylor, J., Anderson, N.L., Coulter, B.P., Scandora, A.E., and Anderson, N.G. Electrophoresis '79, B. Radola, ed. W. deGruyter, pp 329-339, 1980.


27.      A method for studying proteins in 2-D gels using thermal denaturation analysis. Nance, S.L., Hickman, B.J., and Anderson, N.L. Electrophoresis '79 B. Radola, ed. W. deGruyter, pp 351-360, 1980.


28.      Automatic chemistry and the human protein index. Anderson, N.G., and Anderson, L. Automatic Chemistry 2: 177-179, 1980.


29.      A variant of human non-muscle tropomyosin found in fibroblasts by using two-dimensional electrophoresis. Giometti, C.S. and Anderson, N.L. J. Biol. Chem. 256, 11840-11846, 1981.


30.      High resolution two-dimensional electrophoretic mapping of immunoglobulin light chains. Anderson, N.L. Immunology Letters 2: 195-199, 1981.


31.      Studies of gene expression in human lymphocytes using high-resolution two-dimensional electrophoresis. Anderson, N.L. Electrophoresis '81 Allen and Arnaud, eds., W. deGruyter, pp 309-316, 1981.


32.      Identification of mitochondrial proteins and some of their precursors in two-dimensional electrophoretic maps of human cells. Anderson, L. Proc. Nat. Acad. Sci. 78, 2407-4211, 1981.


33.      The TYCHO system for computerized analysis of two-dimensional gel protein mapping data. Anderson, N.L., Taylor, J., Scandora, A.E., Coulter, B.P., and Anderson, N.G. Clin. Chem. 27, 1807-1820, 1981.


34.      A computerized system for matching and stretching two-dimensional gel patterns represented by parameter lists. Taylor, J., Anderson, N.L., and Anderson, N.G. Electrophoresis '81, Allen and Arnaud, eds., W. deGruyter, pp 383-400, 1981.


35.      Use of high-resolution two-dimensional electrophoresis in human health effects studies. Anderson, N.G. and Anderson, N.L. in: Health Risk Analysis, Chapter 27, Oak Ridge Symposium, pp 357-365, 1981.


36.      The human protein index. Anderson, Norman G. and Anderson, N. L. JAMA, 246, 2621, 1981.


37.      The human protein index: Relationship to genetic engineering. Anderson, N.G. and Anderson, N.L. Proceeding of the 1981 Battelle Conference on Genetic Engineering, Reston, VA, April 6-10, 1981, Keenberg, M., ed., Vol. IV, 1981, pp 163-170.


38.      The potential of high resolution protein mapping as a method of monitoring the human immune system. In: Biological Relevance of Suppression. Anderson, N.L. and Anderson, N.G., Dean, J.H. and Padarathsingh, M., eds., Van Nostrand Reinhold Company, NY, Chap. 9, pp 136-147, 1981.


39.      The human protein index project and the molecular pathology database. Anderson, N.G. and Anderson, N.L. Medical Laboratory 11, 75-94, 1982.


40.      The human protein index. Anderson, N.G. and Anderson, N.L. Clin. Chem. 28, 739-748, 1982.


41.      Towards a complete catalogue of human proteins. Anderson, N.L. Trends in Analytical Chemistry 1, 131-135, 1982.


42.      Design and implementation of a prototype human protein index. Taylor, J., Anderson, N.L., Scandora, A.E., Jr., Willard, K.E., and Anderson, N.G. Clin. Chem. 28, 861-866, 1982.


43.      Lymphocyte, monocyte and granulocyte proteins compared by use of two-dimensional electrophoresis. Gemmell, M.A. and Anderson, N.L. Clin. Chem. 28, 1062-1066, 1982.


44.      A two-dimensional electrophoretic analysis of the heat shock-induced proteins of human cells. Anderson N.L., Giometti, C.S., Gemmell, M.A., Nance, S.L., and Anderson, N.G. Clin. Chem. 28, 1084-1092, 1982.


45.      Cytoskeletal proteins from human skin fibroblasts, peripheral blood leukocytes, and a lymphoblastoid cell line compared by two-dimensional gel electrophoresis. Giometti, C.S., Willard, K.E., and Anderson, N.L. Clin. Chem. 28, 955-961, 1982.


46.      Specific antiserum staining of two-dimensional electrophoretic patterns of human plasma proteins immobilized on nitrocellulose. Anderson, N.L., Nance, S.L., Pearson, T.W., and Anderson, N.G. Electrophoresis 3, 135-142, 1982.


47.      Genetic engineering, monoclonal antibodies, clinical chemistry, replacement therapy and the human protein index. Anderson, N.G. and Anderson, N.L. Laboratory Management Magazine, 1982.


48.      Use of two-dimensional electrophoresis to study the comparative molecular anatomy of human cells types. Anderson, N.L. in Proceedings of Biologie Prospective - 5th Colloque International de Pont-ˆ-Mousson, Galteau, M.M., Siest, G., and Henny, J., eds., Masson, Paris, pp 75-78, 1983.


49.      Applications of two-dimensional gel electrophoresis in the clinical laboratory. Tracy, R.P. and Anderson, N.L. in Clinical Laboratory Annual, Homburger, H.A. and Butsakis, J.G., eds., Appleton-Century-Crofts, Connecticut, pp 101-130, 1983.


50.      Image analysis and interactive data base manipulation applied to two-dimensional maps of human proteins. Anderson, N.L., Taylor, J., and Anderson, N.G., Proc. National Computer Graphics Association, June 26-30, pp 69-76, 1983.


51.      Analysis of human leukemia cells by use of high-resolution two-dimensional electrophoresis. I: Results of a pilot study. Anderson, N.L., Wiltsie, J.C., Li, C.Y., Willard-Gallo, K.E., Tracy, R.P., Young, D.S., Powers, M.T., Anderson, N.G., Clin. Chem. 29, 762-767, 1983.


52.      Numerical measures of 2-D gel resolution and positional reproducibility. Taylor, J., Anderson, N.L., and Anderson, N.G. Electrophoresis 4, 338-346, 1983.


53.      Use of high-resolution two-dimensional gel electrophoresis for analysis of monoclonal antibodies and their specific antigens. Anderson, N.L. and Pearson, T.W. Methods in Enzymol. 92: 196-200, 1983.


54.      Control of macrophage cell differentiation in human promyelocytic HL-60 leukemia cells by 1,25-dihydroxyvitamin D3 and phorbol-12-myristate-13-acetate. Murao, S., Gemmell, M.A., Callaham, M.F., Anderson, N.L., and Huberman, E. Cancer Res. 43, pp 4989-4996, 1983.


55.      An electrophoretic variant of a human fibroblast protein with characteristics of smooth muscle tropomyosin. Giometti, C.S. and Anderson, N.L. J. Mol. Biol. 173, 109-123, 1984.


56.      Protein variants in human cells: Enumeration by protein indexing. Anderson, N.L., Giometti, C.S., Gemmell, M.A., and Macy, M.A. New York Acad. Sci., 428, 134-143, 1984.


57.      High resolution two-dimensional electrophoretic mapping of plasma proteins. Anderson, N.L., Tracy, R.P., and Anderson, N.G. in: The Plasma Proteins, F. Putnam, ed. Academic Press, 2nd ed., Vol. 3, pp 221-270, 1984.


58.      Two-dimensional electrophoresis used to differentiate the causal agents of American Tegumentary Leishmaniasis. Saravia, N.G., Gemmell, M.A., Nance, S.L., and Anderson, N.L. Clin. Chem. 30, 2048-2052, 1984.


59.      Tropomyosin heterogeneity in human cells. Giometti, C.S. and Anderson, N.L. J. Biol. Chem., 259, 14113-14120, 1984.


60.      Protein pattern changes and morphological effects due to methionine starvation or 5-azacytidine treatment of the phorbol-ester-sensitive cell lines HL-60, CCL-119, and U-937. Anderson, N.L. and Gemmell, M.A. Clin. Chem. 30, 1956-1963, 1984.


61.      Global approaches to the quantitative analysis of gene expression patterns observed by two-dimensional gel electrophoresis. Anderson, N. L., Hofmann, J-P., Gemmell, A. and Taylor, J. Clin. Chem. 30, 2031-2036, 1984.


62.      Introduction: Some perspectives on two-dimensional protein mapping. Anderson, L. and Anderson, N. Clin. Chem. 30, 1898-1905, 1984.


63.      High resolution two-dimensional electrophoresis as a method of identifying organisms and cell types. Anderson, N.L. Proc. of a WHO Symposium on Application of Biochemical and Molecular Biology Techniques to Proteins for Parasite and Vector Identification, 1984.


64.      Comparison of organisms and cell types using two-dimensional electrophoresis. Anderson, N.L. in: Uses and Standardization of Vertebrate Cell Cultures, Monograph No. 5, Stevenson, R.E., ed., Tissue Culture Association, pp 189-195, 1984.


65.      Two-dimensional electrophoretic analysis of wheat seed proteins. Anderson, N.G., Tollaksen, S., Pascoe, F., and Anderson, N.L. Crop Science 25, 667-674, 1985.


66.      Specific protein phosphorylation in human promyelocytic HL-60 leukemia cells susceptible or resistant to induction of cell differentiation by phorbol-12-myristate-13-acetate. Anderson, N.L., Coussens, M.A., Murao, S., and Huberman, E. Cancer Res. 45, 4955-4962, 1985.


67.      Two different variants of the same tropomyosin polypeptide in clones from GM1386 human skin fibroblasts. Giometti, C.S., Gemmell, M.A., and Anderson, N.L., Biochem. Biophys. Res. Comm. 128, 1247-1253, 1985.


68.      Comparison of African trypanosomes of different antigenic phenotype, subspecies and life cycle stages by two-dimensional electrophoresis. Anderson, N.L., Parrish, N, Richardson, J., and Pearson, T.W. Biochem. Parasitol. 16, 299-314, 1985.


69.      Quantitative reproducibility of measurements from Coomassie Blue-stained two-dimensional electrophoresis gels: Analysis of mouse liver protein patterns and a comparison of BALB/c and C57 strains. Anderson, N.L., Nance, S.L. Tollaksen, S.L., Giere, F.A., and Anderson, Norman G., Electrophoresis 6, 592-599, 1985.


70.      A policy and program for biotechnology. Anderson, N.G. and Anderson, N.L. American Biotechnology Laboratory, Sept/Oct, 1985.


71.      Use of large-scale two-dimensional ISODALT gel electrophoresis system in immunology. Lefkovits, I., Young, P., Kuhn, L., Kettman, J., Gemmell, A., Tollaksen, S., Anderson, L., and Anderson, N. In: Immunological Methods, Vol. III, Lefkovits, Ivan and Pernis, Benvenuto, eds., Academic Press, Inc., Orlando, Chapter 11, pp 163-185, 1985.


72.      Induction of a mitochondrial matrix protein in human fibroblasts by interferon or poly I:C. Anderson, N.L., Electrophoresis 6: 277-282, 1985.


73.      Effects of Aroclor 1254 on proteins of mouse liver. Application of 2-D electrophoretic protein mapping. Anderson, N.L., Nance, S.L., Tollaksen, S.L., Giere, F.A., and Anderson, N.G. Electrophoresis 7, 44-48, 1986.


74.      Differences between 2-D electrophoretic protein patterns of livers of male and female mice. Anderson, N.L., Giere, F.A., Nance, S.L., Gemmell, M.A., Tollaksen, S.L., and Anderson, N.G. Electrophorese Bidimensionelle, Press Univ. Nancy, 1986, pp 253-260.


75.      Suitability of two-dimensional electrophoretic protein separations for quantitative detection of mutations. Taylor, J., Anderson, N.L., Anderson, N., Gemmell, A., Giometti, C., Sharron L., and Tollaksen, S.L. Electrophoresis '86, Dunn, M.J., ed., Verlag Chemie GmbH, Weinheim, pp 583-587, 1986.


76.      Effects of toxic agents at the protein level: Quantitative measurements of 213 mouse liver proteins following xenobiotic treatment. Anderson, N.L., Giere, F.A., Nance, S.L., Gemmell, M. A., Tollaksen, S.L., and Anderson, N.G. Fundamental and Applied Toxicology, 8, 39-50, 1987.


77.      Application of high-resolution, two-dimensional electrophoresis to the analysis of wheat, milk, and other agricultural products. Anderson, N.G. and Anderson, N.L. in: New Directions in Electrophoretic Methods, Jorgenson, James W. and Phillips, Marshall, eds., ACS Symposium Series No. 335: 132-142, 1987.


78.      Expression of cloned sequences in biopsies of human colonic tissue and in colonic carcinoma cells induced to differentiate in vitro. Augenlicht, L.H., Wahrman, M.Z., Halsey, H., Anderson, L., Taylor, J., and Lipkin, M. Cancer Research 47: 6017-6021, 1987.


79.      New architectures appropriate for large 2-D gel databases. Anderson, Leigh, Electrophoresis '88, Schafer-Nielsen, Claus, ed., The Protein Laboratory, University of Copenhagen, distributed by VCH Verlagsgesellschaft mbH, pp313-321, 1988.


80.      Research instrumentation for the 21st century: Progress toward complete genomic maps and sequence data bases and indexes of protein gene products. Anderson, N.G., Anderson, N.L., and Hofmann, J.-P. in: Research Instrumentation for the 21st Century, USDA Symposium Series No. 11, Beecher, Gary B., ed., Martinus Nijhoff Publishers, Dordrecht, Chapter 6, pp 117-128, 1988.


81.      Technical improvements in 2-D gel quality and reproducibility using the ISO-DALTŠ system. Anderson, L., Hofmann, J.-P., Anderson, E., Walker, B. and Anderson, N.G. in: Two-Dimensional Electrophoresis, Endler, A.T.and Hanash, S., eds., VCH Verlagsgesellschaft mbH, Weinheim, pp 288-297, 1989.


82.      Measurement of drug-induced changes in hundreds of liver proteins: Developing a molecular pathology. Anderson, L. in: New Horizons in Toxicology, Eli Lilly Symposium, Probst, Gregory S., Vodicnik, Mary Jo and Dorato, Michael A., eds., FASEB, Bethesda, MD, pp 65-71, 1991, ISBN 0-913822-18-3.


83.      Patterns of gene expression which characterize the colonic mucosa in patients at genetic risk for colonic cancer. Augenlicht, L.H., Taylor, J., Anderson, N.L., and Lipkin, M. Proc. Nat. Acad. Sci. USA, 88, pp 3286-3289, 1991.


84.      A two-dimensional gel database of human plasma proteins. Anderson, N.L. and Anderson, N.G. Electrophoresis 12: 883-906, 1991.


85.      A two-dimensional gel database of rat liver proteins useful in gene regulation and drug effects studies. Anderson, N.L., Esquer-Blasco, R., Hofmann, J.-P., and Anderson, N.G. Electrophoresis, 12, 907-930, 1991.


86.      Two-dimensional gel electrophoretic analysis of human lens proteins. Datiles, M.B., Schumer, D.J., Zigler, Jr., J.S., Russell, P., Anderson, L. and Garland, D. Current Eye Research 11: 669-677, 1992.


87.      Two-dimensional gel electrophoresis analysis of Syrian hamster embryo cells: Morphological transformation is not cell type specific. Isfort, R.J., Kerckaert, G., Anderson, N.L., and LeBoeuf, R.A. Electrophoresis 13, 855-861, 1992.


88.      Covalent protein modifications and gene expression changes in rodent liver and hepatocyte systems following administration of methapyrilene: a study using two-dimensional electrophoresis. Anderson, N.L., Copple, D.C., Bendele, R.A., Probst, G.S., and Richardson, F.C. Fundamental and Applied Toxicology, 18, 570-580, 1992.


89.      Comparisons of protein changes in human and rodent hepatocytes induced by the rat-specific carcinogen, methapyrilene. Richardson, F.C., Strom, S.C., Copple, D.M., Bendele, R.A., Probst, G.S., and Anderson, N.L. Electrophoresis 14, 157-161, 1993.


90.      Two-dimensional electrophoresis as applied to problems of in vitro and in vivo toxicology. Anderson, N.L., Esquer-Blasco, R. and Anderson, N.G. in: Methods in Toxicology: In Vitro Toxicity Indicators, Tyson, Charles A. and Frazier, John M., eds., Academic Press, Inc., pp. 463-473, 1994.


91.      Dose-responses in rat hepatic protein modification and expression following exposure to the rat hepatocarcinogen methapyrilene. Richardson, F.C., Horn, D.M., and Anderson, N.L. Carcinogenesis 15, 325-329, 1994.


92.      The hepatocarcinogen methapyrilene but not the analog pyrilamine induces sustained hepatocellular replication and protein alterations in F344 rats in a 13 week feed study. Cunningham, M.L., Pippin, L.L., Anderson, N.L., and Wenk, M.L. Toxicology and Applied Pharmacology, 131, 216-223, 1995.


93.      Effects of oltipraz and related chemoprevention compounds on gene expression in rat liver. Anderson, L., Steele, V.K., Kelloff, G.J., and Sharma, S. Journal of Cellular Biochemistry, Supplement 22, 108-116, 1995.


94.      A comparative study of mouse liver proteins arylated by reactive metabolites of acetaminophen and its nonhepatotoxic regioisomer, 3Õ-hydroxyacetanilide. Myers, T.G., Dietz, E.C., Anderson, N.L., Khairallah, E.A., Cohen, S.D., and Nelson, S.D. Chem. Res. Toxicol. 8: 403-413, 1995.


95.      An updated two-dimensional gel database of rat liver proteins useful in gene regulation and drug effects studies. Anderson, N.L., Esquer-Blasco, R., Hofmann, J.-P., Meheus, L., Raymackers, J., Steiner, S., Witzmann, F., and Anderson, N.G. Electrophoresis, 16, 1977-1981, 1995.


96.      Large-Scale Oligonucleotide Synthesizers: 1. Basic Principles & system design Anderson, N.G., Anderson, N.L., Taylor, J. and Goodman, J. Appl Biochem Biotechnol 54, 19-42, 1995.


97.      The effects of peroxisome proliferators on protein abundances in mouse liver. Anderson, N. L., Esquer-Blasco, R., Richardson, F., Foxworthy, P and Eacho, P. Toxicology and Applied Pharmacology, 137, 75-89, 1996.


98.      Cyclosporine A decreases the protein level of the calcium-binding protein calbindin-D 28kDa in rat kidney. Steiner, S, Aicher L, Cordier A, Raymackers J, Meheus L, Esquer-Blasco R, and Anderson L. Biochem Pharmacol 51: 253-258, 1996


99.      Simultaneous measurement of hundreds of liver proteins: Application in assessment of liver function. Anderson, N.L., Taylor, J., Hofmann, J-P., Esquer-Blasco, R., Swift, S., and Anderson, N.G. Toxicologic Pathology, 24, 72-76, 1996.


100.   Induction of the adipose differentiation-related protein in liver of Etomoxir treated rats. Steiner, S., Wahl, D., Mangold, B., Robison, R., Raymackers, J., Meheus, L., Anderson, L., and Cordier, A. Biochem, Biophys. Res. Comm., 218, 777-782, 1996.


101.   Twenty Years of Two-Dimensional Electrophoresis: Past, Present and Future. Anderson, N. G. and Anderson, N. L. Electrophoresis, 17, 443-453, 1996.


102.   Rapid mass spectrometric identification of proteins from two-dimensional polyacrylamide gels after in gel proteolytic digestion. Li, G., Waltham, M., and Anderson, N.L., Unsworth, E., Treston, A., Weinstein, J.N. Electrophoresis, 18, 391-402, 1997.


103.   A comparison of selected mRNA and protein abundances in human liver. Anderson, L., and Seilhamer, J. Electrophoresis, 18, 533-537, 1997.


104.   A protein expression database for the molecular pharmacology of cancer. Myers, T.G., Anderson, N.L., Waltham, M., Li, G., Buolamwini, J.K., Scudiero, D.A., Paull, K.D., Sausville, E.A., and Weinstein, J.A. Electrophoresis, 18, 647-653, 1997.


105.   Investigation of ornithine decarboxylase activity acd two-dimensional electrophoretic protein profile following exposure of T24 bladder carcinoma cells to tumor promoter and carcinogen. Kanitz, M.H., Li, E.I., Schulte, P.A., Anderson, N.L., Rothman, N., and Savage, R.E. Jr. Toxicology Methods, 7, 27-41, 1997.


106.   An information-intensive approach to the molecular pharmacology of cancer. Weinstein, J.N., Myers, T.G., OÕConnor, P.M., Friend, S.H., Fornace, A.J., Kohn, K.W., Fojo, T., Bates, S.E., Rubinstein, L.V., Anderson, N.L., Buolamwini, J.K., van Osdol, W.W., Monks, A.P., Scudiero, D.A., Sausville, E.A., Zaharevitz, D.W., Bunow, B., Viswanadhan, V.N., Johnson, G.S., Wittes, R.E., and Paull, K.D. Science, 275, 343-349, 1997.


107.   Analysis of changes in acute phase and other plasma proteins in an acute inflammatory response and in rheumatoid arthritis. Doherty, N.S., Littman, B.H., Reilly, K., Swindell, A.C., Buss, J., and Anderson, N.L. Electrophoresis, 19, 355-363, 1998.


108.   Proteome and proteomics: new technologies, new concepts, and new words. Anderson, N.L., Anderson, N.G. Electrophoresis, 19, 1853-1861, 1998.


109.   Changes in the liver proteome of female Wistar rats treated with the hypoglycemic agent SDZ PGU 693. Arce A, Aicher, L, Wahl D, Esquer-Blasco R, Anderson, NL, Cordier A and Steiner, S. Life Sci, 63, 2243-50, 1998


110.   Cholangiocyte-specific rat liver proteins identified by establishment of a two-dimensional gel protein database. Tietz P, de Groen PC, Anderson NL, Sims C, Esquer-Blasco R, Meheus L, Raymackers J, Dauwe M, LaRusso NF. Electrophoresis 19: 3207-3212, 1998


111.   Confirmed identities of proteins from a two-dimensional map of Syrian hamster embryo cells. Asquith, T.N., Gauggel, D.L., Esquer-Blasco, R., Anderson, N.L., and Isfort, R.J. Electrophoresis 20, 1646-51 (1999).


112.   Proteomics: applications in basic and applied biology. Anderson, N.L., Matheson, A.D. and Steiner, S. Curr Opin in Biotechnol, 11, 2000, 408-412.


113.   Pharmaceutical Proteomics. Steiner, S. and Anderson, N.L. In: Isfort, R.J. and Lederberg, J, eds. Toxicology for the Next Millenium. New York, Annals of the New York Academy of Science, 919, (2000) 48-51.


114.   Two-dimensional electrophoresis of liver proteins: Characterization of a drug-induced hepatomegaly in rats. Newsholme, SJ, Maleeff, BF, Steiner, S, Anderson, NL, Schwartz, LW Electrophoresis 21 (11), June 2000. 2122 – 2128.


115.   Proteomics to display lovastatin-induced protein and pathway regulation in rat liver. Steiner, S, Gatlin, CL, Lennon, JJ, McGrath, AM, Aponte, AM, Makusky, AJ, Rohrs, MC, Anderson, NL. Electrophoresis 21 (11), June 2000. 2129-2137.


116.   Expression profiling in toxicology – potentials and limitations. Steiner, S, Anderson, NL Toxicology Letters 112-113 (2000). 467-471.


117.   Proteomic analysis of the atrophying rat soleus muscle following denervation. Isfort, RJ, Hinkle, RT, Jones, MB, Wang, F, Greis, KD, Sun, Y, Keough, TW, Anderson, NL, Sheldon, RJ. Electrophoresis 21 (11), June 2000. 2228-2234.


118.   Disease-specific alterations in frontal cortex brain proteins in schizophrenia, bipolar disorder, and major depressive disorder. Johnston-Wilson, NL, Sims, CD, Hofmann, J-P, Anderson, NL, Shore, AD, Torrey, EF, Yolken,RH. Molecular Psychiatry (2000) 5, 142-149


119.   Cholesterol biosynthesis regulation and protein changes in rat liver following treatment with fluvastatin. Steiner, S., Gatlin, C.L., Lennon, J.J., McGrath, A.M., Seonarain, M.D., Makusky, A.J., Aponte, A.M., Esquer-Blasco, R., and Anderson, N.L. Toxicol Lett 120, 369-77 (2000).


120.   Back to the future: the Human Protein Index and the agenda for post-proteomic biology. Anderson, NG, Matheson, A, and Anderson, NL, Proteomics (2001) 1, 3-12


121.   Proteomic analysis of rat soleus and tibialis anterior muscle following immobilization. Isfort, R.J., Wang, F., Greis, K.D., Sun, Y., Keough, T.W., Bodine, S.C., and Anderson, N.L. J Chromatogr B Analyt Technol Biomed Life Sci 769, 323-32 (2002).

122.   Proteomic analysis of rat soleus muscle undergoing hindlimb suspension-induced atrophy and reweighting hypertrophy. Isfort, R.J., Wang, F., Greis, K.D., Sun, Y., Keough, T.W., Farrar, R.P., Bodine, S.C., and Anderson, N.L., Proteomics 2, 543-50 (2002).

123.   The human plasma proteome: History, character, and diagnostic prospects. Anderson, N.L. and Anderson, N.G., Molecular and Cellular Proteomics, 1.11, 845-867 (2002)

124.   The human serum proteome: Display of nearly 3700 chromatographically separated protein spots on two-dimensional electrophoresis gels and identification of 325 distinct proteins. Pieper, R., Gatlin, C. L., Makusky, A. J., Russo, P. S., Schatz, C. R., Miller, S. S., Su, Q., McGrath, A. M., Estock, M. A., Parmar, P. P., Zhao, M., Huang, S. T., Zhou, J., Wang, F., Esquer-Blasco, R., Anderson, N. L., Taylor, J., Steiner, S. Proteomics 3(7): 1345-64. (2003).

125.   Multi-component immunoaffinity subtraction chromatography: An innovative step towards a comprehensive survey of the human plasma proteome. Pieper, R., Su, Q., Gatlin, C. L., Huang, S. T., Anderson, N. L., Steiner, S. Proteomics 3(4): 422-32 (2003).

126.   Global screening for human viral pathogens. Anderson, N.G., Gerin, J.L., and Anderson, N.L. Emerging Infectious Diseases 9:768-773 (2003).

127.   Therapeutic potential of the plasma proteome. Lathrop, J.T., Anderson, N.L., Anderson, N.G., and Hammond, D.J. Current Opinion in Mol. Therapeutics 5:250-257 (2003).

128.   An effective and rapid method for functional characterization of immunoadsorbents using POROS¨ beads and flow cytometry. N. Leigh Anderson, N.L., Haines, L.R. and Pearson, T.W. Journal of Proteome Research 3:228-34 (2004).


129.   Mass Spectrometric Quantitation of Peptides and Proteins Using Stable Isotope Standards and Capture by Anti-Peptide Antibodies (SISCAPA). Anderson, N.L., Anderson, N.G., Haines, L.R., Hardie, D.B., Olafson. R.W., and Pearson, T.W. Journal of Proteome Research 3: 235-44 (2004).


130.   NHLBI Clinical Proteomics Working Group Report. Granger, C.B., Van Eyk, J.E., Mockrin, S.C., and Anderson, N.L., on behalf of the Working Group Members. Circulation 109: 1697-703 (2004).


131.   The Human Plasma Proteome: A Non-Redundant List Developed by Combination of Four Separate Sources Anderson, N.L., Polanski, M., Pieper, R., Gatlin, T., Tirumalai, R.S., Conrads, T.P., Veenstra, T.D., Adkins, J.N., Pounds, J.G, Fagan, R., and Lobley, A., Mol Cell Proteomics 3: 311-326 (2004).


132.   Candidate-Based Proteomics in the Search for Biomarkers of Cardiovascular Disease, Leigh Anderson, J. Physiol., 563.1:23-60 (2005).


133.   The Roles of Multiple Proteomics Platforms in a Pipeline for New Diagnostics, N. Leigh Anderson, Mol Cell Proteomics, 4:1441–1444 (2005).


134.   Proteomics: From Basic Research to Diagnostic Application. A Review of Requirements & Needs, Frank Vitzthum, Fritz Behrens, N. Leigh Anderson, and John H. Shaw, J. Proteom. Res. 4:1086–1097 (2005).


135.   Perspective: A Program to Improve Protein Biomarker Discovery for Cancer, Ruedi Aebersold, Leigh Anderson, Richard Caprioli, Brian Druker, Leland Hartwell, and Richard Smith, J. Proteom. Res. 4:1104–1109 (2005).


136.   Quantitative Mass Spectrometric MRM Assays for Major Plasma Proteins, Leigh Anderson and Christie Hunter, Mol Cell Proteomics 5: 573-588 (2006).


137.   A List of Candidate Cancer Biomarkers for Targeted Proteomics. Malu Polanski and Leigh Anderson, Biomarker Insights 2: 1-48 (2006).


138.   A reagent resource to identify proteins and peptides of interest for the cancer community: a workshop report. Haab BB, Paulovich AG, Anderson NL, Clark AM, Downing GJ, Hermjakob H, Labaer J, Uhlen M., Mol Cell Proteomics 5:1996-2007 (2006).


139.   Head-to-head comparison of serum fractionation techniques. Whiteaker JR, Zhang H, Eng JK, Fang R, Piening BD, Feng LC, Lorentzen TD, Schoenherr RM, Keane JF, Holzman T, Fitzgibbon M, Lin C, Zhang H, Cooke K, Liu T, Camp DG 2nd, Anderson L, Watts J, Smith RD, McIntosh MW, Paulovich AG. J Proteome Res. 2007 Feb;6(2):828-36.


140.   Antibody-based enrichment of peptides on magnetic beads for mass-spectrometry-based quantification of serum biomarkers. J. R. Whiteaker, L. Zhao, H. Y. Zhang, L-C Feng, B. D. Piening, L. Anderson and A. G. Paulovich, Analytical Biochemistry 362:44–54 (2007).


141.   Metrological sharp shooting for plasma proteins and peptides: The need for reference materials for accurate measurements in clinical proteomics and in vitro diagnostics to generate reliable results. Frank Vitzthum, G Patric Hoerth, Peter Schulz-Knappe, Harald Tammen, Juergen Adamkiewicz and N. Leigh Anderson, Proteomics Clin. Appl. 1:1016-1035 (2007)


142.   Candidate List of yoUr Biomarker (CLUB): a Web-based Platform to Aid Cancer Biomarker Research. Bernett T. K. Lee, Lailing Liew, Jiahao Lim, Jonathan K. L. Tan, Tze Chuen Lee, Pardha S. Veladandi, Yun Ping Lim, Hao Han, Gunaretnam Rajagopal, N. Leigh Anderson, Biomarker Insights 3:65–71 (2008).


143.   Guidelines for reporting the use of gel electrophoresis in proteomics. Frank Gibson, Leigh Anderson, Gyorgy Babnigg, Mark Baker, Matthias Berth, Pierre-Alain Binz, Andy Borthwick, Phil Cash, Billy W Day1, David B Friedman, Donita Garland, Howard B Gutstein, Christine Hoogland, Neil A Jones, Alamgir Khan, Joachim Klose, Angus I Lamond, Peter F Lemkin, Kathryn S Lilley, Jonathan Minden, Nicholas J Morris, Norman W Paton, Michael R Pisano, John E Prime, Thierry Rabilloud, David A Stead, Chris F Taylor, Hans Voshol, Anil Wipat & Andrew R Jones, Nature Biotechnology 26, 863 - 864 (2008)


144.   High-Abundance Polypeptides of the Human Plasma Proteome Comprising the Top 4 Logs of Polypeptide Abundance. Glen L. Hortin, Denis Sviridov and N. Leigh Anderson, Clinical Chemistry 54: 1608-1616 (2008)


145.   Protein Quantitation through Targeted Mass Spectrometry: The Way Out of Biomarker Purgatory? Steven A. Carr and Leigh Anderson, Clinical Chemistry 54:11, 1749–1752 (2008)


146.   Anti-peptide antibody screening: selection of high affinity monoclonal reagents by a refined surface plasmon resonance technique. Matthew E. Pope, Martin V. Soste, Brett A. Eyford, N. Leigh Anderson and Terry W. Pearson, J Immunol Methods, 341(1-2):86-96 (2009)


147.   A Human Proteome Detection and Quantitation Project: hPDQ. N. Leigh Anderson, Norman G. Anderson, Terry W. Pearson, Christoph H. Borchers, Amanda G. Paulovich, Scott D. Patterson , Ruedi Aebersold and Steven A. Carr, Mol Cell Proteomics 8:883-886 (2009)


148.   SISCAPA Peptide Enrichment on Magnetic Beads Using an Inline Beadtrap Device. N. Leigh Anderson, Angela Jackson, Derek Smith, Darryl Hardie, Christoph Borchers, and Terry W. Pearson, Mol Cell Proteomics 8:995-1005 (2009)


149.   MRM-based, Multiplexed, Absolute Quantitation of 45 Proteins in Human Plasma Michael A. Kuzyk, Derek Smith, Juncong Yang, Tyra Cross, Angela Jackson, Darryl Hardie, N. Leigh Anderson, and Christoph H. Borchers, Molec. Cell. Proteomics, 8(8):1860-77 (2009)


150.   A Multi-site Assessment of Precision and Reproducibility of Multiple Reaction Monitoring-based Measurements by the NCI-CPTAC Network: Toward Quantitative Protein Biomarker Verification in Human Plasma. Terri Addona, Susan E. Abbatiello, Birgit Schilling, Steven J. Skates, D. R. Mani, David M. Bunk, Clifford H. Spiegelman, Lisa J. Zimmerman, Amy-Joan L. Ham, Hasmik Keshishian, Steven C. Hall, Simon Allen, Ronald K. Blackman, Christoph H. Borchers, Charles Buck, Helene L. Cardasis, Michael P. Cusack, Nathan G. Dodder, Bradford W. Gibson, Jason M. Held, Tara Hiltke, Angela Jackson, Eric B. Johansen, Christopher R. Kinsinger, Jing Li, Mehdi Mesri, Thomas A. Neubert, Richard K. Niles, Trenton C. Pulsipher, David Ransohoff, Henry Rodriguez, Paul A. Rudnick, Derek Smith, David L. Tabb, Tony J. Tegeler, Asokan M. Variyath, Lorenzo J. Vega-Montoto, sa Wahlander, Sofia Waldemarson, Mu Wang, Jeffrey R. Whiteaker, Lei Zhao, N. Leigh Anderson, Susan J. Fisher, Daniel C. Liebler, Amanda G. Paulovich, Fred E. Regnier, Paul Tempst, and Steven A. Carr. Nature Biotechnology, 27(7):633-41 (2009)


151.   An automated and multiplexed method for high throughput peptide immunoaffinity enrichment and multiple reaction monitoring mass spectrometry-based quantification of protein biomarkers. Jeffrey R. Whiteaker, Lei Zhao, Leigh Anderson, and Amanda G. Paulovich, Molec. Cell. Proteomics, in press 2009


152.   The Clinical Plasma Proteome: A Survey of Clinical Assays for Proteins in Plasma and Serum, N. Leigh Anderson, Clin. Chem, in press 2009


153.   Advances in Protein Analysis for the Clinical Laboratory, Glen L. Hortin, Steven A. Carr, N. Leigh Anderson, Clin. Chem, in press 2009


154.    Sweetening the pot: adding glycosylation to the biomarker discovery equation. Penelope M. Drake, Wonryeon Cho, Bensheng Li, Akraporn Prakobphol, Eric Johansen, N. Leigh Anderson, Fred E. Regnier, Bradford W. Gibson and Susan J. Fisher, Clin. Chem. in press 2009.


155.   Proteomic-Based Multiplex Assay Mock Submissions: Supplementary Material to A Workshop Report by the NCI-FDA Interagency Oncology Task Force on Molecular Diagnostics, Fred E. Regnier, Steven J. Skates, Mehdi Mesri, Henry Rodriguez, Živana Težak, Marina V. Kondratovich, Michail A. Alterman, Joshua D. Levin, Donna Roscoe, Eugene Reilly, James Callaghan, Kellie Kelm, David Brown, Reena Philip, Steven A. Carr, Daniel C. Liebler, Susan J. Fisher, Paul Tempst, Tara Hiltke, Larry G. Kessler, Christopher R. Kinsinger, David F. Ransohoff, Elizabeth Mansfield4 and N. Leigh Anderson, Clin Chem, to be submitted










Two-Dimensional Electrophoresis: Operation of the ISO-DALT‰ System. Leigh Anderson, Large Scale Biology Press, Washington D.C., 1991, ISBN 0-945532-01-6, 200pp.



Patents (40 issued US patents, 39 published pending US applications)


1.              6,846,635        Microarrays and their manufacture

2.              6,783,648        Method and apparatus for unloading gels from isoelectric gel tubes

3.              6,761,810        Automated apparatus including a robotic arm for loading samples into wells for first dimension electrophoresis separation

4.              6,713,309        Microarrays and their manufacture

5.              6,653,151        Dry deposition of materials for microarrays using matrix displacement

6.              6,652,724        Automated apparatus for separating a biological sample from a two dimensional electrophoresis gel

7.              6,649,419        Method and apparatus for protein manipulation

8.              6,643,391        Apparatus for computer-assisted isolation and characterization of proteins

9.              6,554,991        Automated system for two-dimensional electrophoresis

10.           6,539,102        Reference database

11.           6,537,434        First dimension electrophoresis separation method and apparatus

12.           6,513,813        Gel slab sealing strip for an electrophoresis tank

13.           6,508,986        Devices for use in MALDI mass spectrometry

14.           6,507,664        Two-dimensional gels for separation, identification and characterization of biomolecules

15.           6,485,623        Method and device for forming angled wells in an electrophoresis gel slab

16.           6,482,303        Automated system for two-dimensional electrophoresis

17.           6,479,239        Detection and characterization of microorganisms

18.           6,451,189        Automated system for two dimensional electrophoresis

19.           6,438,259        Computer-assisted methods and apparatus for identification and characterization of biomolecules

20.           6,416,644        Automated system for two-dimensional electrophoresis

21.           6,398,932        Automated system for two-dimensional electrophoresis

22.           6,391,650        Protein sample preparation for electrophoresis

23.           6,346,421        Methods for concentrating and detecting microorganisms using centrifuge tubes

24.           6,340,570        Detection and characterization of microorganisms

25.           6,298,874        Slab gel processing tank

26.           6,254,834        Detection and characterization of microorganisms

27.           6,245,206        Automated system for two-dimensional electrophoresis

28.           6,136,173        Automated system for two-dimensional electrophoresis

29.           6,123,821        Automated system for two-dimensional electrophoresis

30.           5,993,627        Automated system for two-dimensional electrophoresis

31.           5,273,656        System for solid phase reactions

32.           5,272,075        System for solid phase reactions

33.           5,186,824        System for solid phase reactions

34.           4,938,591        Method and apparatus for electronic and visual image comparing

35.           4,929,972        Method and apparatus for electronic and photographic image recording

36.           4,839,016        Curved surface cassette/gel system

37.           4,747,919        Apparatus and method for electrophoresis in tubes

38.           4,594,064        Automated apparatus for producing gradient gels

39.           4,169,036        System for loading slab-gel holders for electrophoresis separation

40.           4,088,561        Apparatus for electrophoresis separation


Published pending:


1.              20080217254  Magnetic bead trap and mass spectrometer interface

2.              20070092924  Process for treatment of protein samples

3.              20060154318  Stable isotope labeled polypeptide standards for protein quantitation

4.              20040072251  High sensitivity quantitation of peptides by mass spectrometry





Privately Printed Works (primarily LSBC)


1.     Pharmaceutical Proteomics brochure (LSBC)